Inventi Impact - Biomedical Analysis
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Biomedical Analysis’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on biomedical analytical techniques including method development, instrumentation, computation and interpretation from academic, clinical and industrial perspectives. The journal accepts papers related to analytical aspects of traditional folk medicines, drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling, analytical biochemistry, forensic toxicology and quality assurance.
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BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF LURASIDONE HYDROCHLORIDE USING RP-HPLC IN RAT PLASMA
A simple, precise, rapid and sensitive bioanalytical RP-HPLC method was developed for estimation of lurasidone HCl in rat plasma. The work carried out using Purospher® STAR Hibar® 250 mm C18 (4.6 mm × 25 cm, packed with 5 particles) column equipped with Shimadzu LC-2010 CHT HPLC system with mobile phase containing acetonitrile: methanol: 0.01M sodium phosphate monobasic buffer (pH 4) in the rat...
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REVERSED PHASE HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF SUMATRIPTAN SUCCINATE NANOPARTICLES IN RAT PLASMA AND BRAIN HOMOGENATE
A rapid, specific and precise reversed phase high performance liquid chromatographic method, with UV detection, was developed for the quantification of sumatriptan succinate loaded in chitosan solid lipid nanoparticles in rat plasma and brain homogenate samples. Rizatriptan benzoate was used as the internal standard and an efficient liquid-liquid extraction technique was employed for extraction fr...
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METHOD VALIDATION AND DETERMINATION OF EPRINOMECTIN IN SHEEP PLASMA AND MILK BY HPLC WITH FLUORESCENCE DETECTION
The objective of the present study was to study the method validation and determination of eprinomectin in sheep plasma and milk following subcutaneous administration at a dose of 0.2 mg.kg-1. The study was conducted using six healthy lactating sheep. Eprinomectin is a novel and potent antiparasitic animal health drug. This paper describes a method for the determination of eprinomectin in sheep pl...
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DETERMINATION OF ATAZANAVIR IN RABBIT PLASMA BY LC-MS/MS AND ITS APPLICATION TO PHARMACOKINETIC STUDY
A simple and rapid liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method has been developed and validated for quantification of protease inhibitor atazanavir in rabbit plasma. Saquinavir was used as an internal standard. The analytes were extracted from rabbit plasma samples by solid-phase extraction technique using Orpheus C18 extraction cartridges. The reconstituted samples wer...
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IN-VIVO INTERACTION STUDY OF MOXIFLOXACIN WITH CALCIUM AND IRON SUPPLEMENT
Moxifloxacin is a fourth generation synthetic fluoroquinolone antibacterial agent active against gram negative and gram positive bacteria. Clinical studies show that cationic preparation decreases absorption of various quinolone antibiotics to a great extant. The objective of the study was to develop and validate a simple chromatographic method for estimating moxifloxacin in analytical and bioanal...
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HPLC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF SITAGLIPTIN IN BLOOD PLASMA
A simple, precise and specific reverse phase high performance liquid chromatographic method has been developed and validated for the determination of sitagliptin in blood. The HPLC separation was carried out by reverse phase chromatography on Shimadzu HPLC system consisted of welchrom 5 ? C18 column (250 X 4.6 mm), SPD 10A UV detector and LC 10 AD pumps. Rheodyne injector with 20 ?l capacity, mobi...
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