Inventi Impact - Animal Models & Cell Assays
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Animal Models & Cell Assays’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on multidimensional aspects of animal models and cell assays particularly leading to bio-profiling and drug development. The journal accepts articles based on in-vivo studies, as well as in-vitro.
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IN-VITRO EVALUATION OF ORANGE ALBEDO AND GRAPE SEED EXTRACTS ANTICANCER POTENTIALS AGAINST BREAST AND COLORECTAL CANCER CELL LINES
Orange albedo (OW/OE) and grape seed extracts (GW/GE) were considered for their medical potentials against carcinoma cells due to their bioflavonoid derivatives. Cytotoxic activity of the OA and GSEs were investigated against breast (MCF-7) and colorectal (HCT-116) cancer cell lines using MTT assay. Moreover, cell cycle distribution by flow cytometry and RTPCR were conducted. Data recorded reveale...
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EFFECT OF BEE VENOM AND OTHER NATURAL PRODUCT (DATES) ON LUNG CANCER: IN-VITRO TRIAL
Bee venom has special pharmacological activity for its enzymes and peptides containment. Melittin is the bee venom’s main constituent. The present work aimed in-vitro estimation of the anti-cancer potentials of bee venom (BV) in addition to evaluation of the synergetic potential of dates extract to bee venom against lung cancer (A549). BV showed a higher toxicity to A549 cells accompanied w...
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GRAPE SEED EXTRACT INDUCES G2/M CELL CYCLE ARREST AND APOPTOSIS VIA GENERATION OF REACTIVE OXYGEN SPECIES IN BREAST AND COLON CANCER CELL LINES
Grape seed as a fruit waste was found to have medicinal potentials, specially its procyanidine containment. The present work aimed to investigate the anticancer potential against two of the mostly spread cancers worldwide namely breast and colon cancers. Data recorded revealed that grape seed extract (GSE) demonstrated a dose dependent cytotoxic potential with an IC50 values of 148.5 and 190.2 ÃŽÂ...
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EVALUATION OF CYTOTOXICITY OF METHANOLIC EXTRACT OF EUPHORBIA HIRTA AGAINST NCIH-522 AND VERO CELL LINE
This study was planned to evaluate cytotoxicity of methanolic extract of E. hirta against NCIH-522 and Vero cell line. Fourier transform infrared spectroscopy (FTIR) analysis of the methanolic extract of E. hirta was performed. 3-(4, 5 dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay was used to perform cytotoxicity study of methanolic extract of E. hirta. Doxorubicin was consid...
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ENDOCRINE DISRUPTOR EFFECTS OF QUINOLINE (CAS:91-22-5) IN THE INTACT JUVENILES/PERIPUBERTAL MALE RATS
The potential effects of the quinoline on pubertal development and thyroid function were quantified in the peripubertal male Wistar rats. Vehicle control (corn oil - 0 mg/kg), positive control – vinclozolin (VCZ - 100 mg/kg) and two groups of quinoline (QNL - 100 and 150/200 mg/kg) were treated from postnatal day (PND) 23–53 at the dose volume of 2.5 ml/kg. Two mortalities, weakness,...
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EVALUATION OF ANTIOBESITY POTENTIAL OF FLAXSEED CONSTITUENTS USING ZEBRAFISH MODEL OF DIET INDUCED OBESITY
Obesity is a global epidemic and a causal factor for many serious ailments and is increasing at alarming rates. Obesity is responsible for about 5% deaths with global economic impact of $2 trillion annually. Flaxseed has great ethnopharmacological relevance. Because of the lipid lowering profile of its constituents it can be used for treatment of Obesity. Flaxseed, a nutraceutical rich in polyunsa...
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