Inventi Rapid - Pharm Analysis & Quality Assurance
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Analysis & Quality Assurance’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutical analysis and quality assurance. It welcomes articles pertaining to qualitative and quantitative analysis of drugs, excipients, and impurities etc. to meet the regulatory requirements; analysis of modern and traditional medicines; quality control methods for biological drugs; quantitative and qualitative analysis in the drug screening processes; tracer analysis in molecular pharmacology; clinical and biological analysis, etc.
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ANALYTICAL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SERTRALINE HYDROCHLORIDE
In the present study simple, precise, rapid, sensitive, accurate and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for sertraline hydrochloride. The chromatographic separation was carried out by using reverse phase stainless steel column of (4.5 mm × 25 cm) Intersil® C18 column with 5 μm (particles packing) held at 25°C. The...
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VALIDATED RP-HPLC METHOD FOR THE ANALYSIS OF DOLUTEGRAVIR IN BULK DRUG
The aim of this present work was to develop and validate a simple, rapid, accurate RP-HPLC method for the estimation of dolutegravir sodium in bulk. Mobile phase consisted of acetonitrile and HPLC water in the ratio of 1:1% v/v and was run through a column of Agilent TC-C18 (2), 5 µm, 4.5×250 nm at a flow rate of 1.5 ml/min and the eluents were monitored at 250 nm. The percent recoveries ranged ...
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DEGRADATION KINETIC STUDY OF DIFLUPREDNATE BY USING VALIDATED STABILITY-INDICATING LIQUID CHROMATOGRAPHIC METHOD
The objective of this investigation was to study the degradation behavior and kinetics of the difluprednate from ophthalmic emulsion under different ICH recommended stress condition by validated stability indicating LC method for quantification of potential known and unknown degradation product. Chromatographic separation was achieved on the C-18 stationary phase with a gradient elution using a mo...
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RP-HPLC METHOD DEVELOPMENT FOR ANALYSIS OF SELECTED SYNTHETIC ANALGESIC AGENTS IN HERBAL FORMULATION
Herbal formulations are popular in worldwide due to safer and not causing any toxicity. Recently there have been reported herbal medicines adulterated with undeclared synthetic drugs. A simple, specific, accurate and isocratic RP-HPLC method was developed and subsequently validated for determination of adulterant. Separation was achieved with a Phenomax Luna C¬18 (250 × 4.5 mm) 5 µm column with...
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A CONCISE REVIEW ON REVERSE PHASE HPLC METHOD DEVELOPMENT AND VALIDATION
RP-HPLC is the most powerful and dominant analytical technique available in todays world of pharmaceutical analysis. This review presented a step-by-step approach to RP-HPLC method development and its validation. Method development, validation and its life cycle management must incorporate in it the concept of QbD and QRM. Exhaustive chromatographic literature review and collecting maximum informa...
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DEVELOPMENT AND VALIDATION OF UV- SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ALOGLIPTIN IN BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD
A simple, sensitive and acute UV spectrophotometric method has been developed for the determination of alogliptin in bulk and pharmaceutical tablet dosage formulation. This method obeys Beer’s law in the concentration range of 3-18 µg/ml with correlation coefficient of 0.9994 and absorption maximum at 272-282 nm in Distilled water. The percentage recovery of alogliptin ranged from 100.05 to 100...
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