Inventi Rapid - Pharm Analysis & Quality Assurance
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharm Analysis & Quality Assurance’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutical analysis and quality assurance. It welcomes articles pertaining to qualitative and quantitative analysis of drugs, excipients, and impurities etc. to meet the regulatory requirements; analysis of modern and traditional medicines; quality control methods for biological drugs; quantitative and qualitative analysis in the drug screening processes; tracer analysis in molecular pharmacology; clinical and biological analysis, etc.
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RP-HPLC METHOD DEVELOPMENT FOR THE DETERMINATION OF RIZATRIPTAN BENZOATE IN BULK DRUG AND TABLET DOSAGE FORM
A simple, rapid, accurate, precise and reproducible RP-HPLC method for the estimation of rizatriptan benzoate in bulk and tablet dosage form was developed and validated as per ICH guidelines. The separation was done using Enable C18 G 150 x 4.6 mm, 5µ column. The mobile phase (water and methanol; 80:20% v/v) was pumped at 1.0 ml/min and effluent was detected at 225 nm using a PDA detector. The re...
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SIMULTANEOUS ESTIMATION OF AMLODIPINE AND AZILSARTAN IN HUMAN PLASMA BY REVERSE PHASE HPLC FOR PHARMOKINETIC STUDIES
Simple and rapid reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated using solid phase extraction (SPE) technique for the determination of azilsartan and amlodipine in human plasma; chromatographic separation of the analyte was achieved at 7.61 min and 18.49 min for amlodipine and azilsartan respectively. HPLC column C 18, 150 X 4.6, 5µ, flow rate was...
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STABILITY INDICATING CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MICONAZOLE AND ORNIDAZOLE IN THEIR PHARMACEUTICAL DOSAGE FORM
The objective of the work was to establish a new, rapid and sensitive RP-HPLC method for determination of two commonly prescribed drug; miconazole and ornidazole. The RP-HPLC separation of the analytes was performed on a hypersil BDS C18 (250 mm x 4.6 mm, 5 µm) column, using isocratic elution of the mobile phase composed of potassium dihydrogen phosphate buffer (pH 3.5) and methanol (70:30 % v/v)...
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ANALYTICAL RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SERTRALINE HYDROCHLORIDE
In the present study simple, precise, rapid, sensitive, accurate and reproducible reverse phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for sertraline hydrochloride. The chromatographic separation was carried out by using reverse phase stainless steel column of (4.5 mm × 25 cm) Intersil® C18 column with 5 μm (particles packing) held at 25°C. The...
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VALIDATED RP-HPLC METHOD FOR THE ANALYSIS OF DOLUTEGRAVIR IN BULK DRUG
The aim of this present work was to develop and validate a simple, rapid, accurate RP-HPLC method for the estimation of dolutegravir sodium in bulk. Mobile phase consisted of acetonitrile and HPLC water in the ratio of 1:1% v/v and was run through a column of Agilent TC-C18 (2), 5 µm, 4.5×250 nm at a flow rate of 1.5 ml/min and the eluents were monitored at 250 nm. The percent recoveries ranged ...
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DEGRADATION KINETIC STUDY OF DIFLUPREDNATE BY USING VALIDATED STABILITY-INDICATING LIQUID CHROMATOGRAPHIC METHOD
The objective of this investigation was to study the degradation behavior and kinetics of the difluprednate from ophthalmic emulsion under different ICH recommended stress condition by validated stability indicating LC method for quantification of potential known and unknown degradation product. Chromatographic separation was achieved on the C-18 stationary phase with a gradient elution using a mo...
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