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Inventi Rapid - Med Chem

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    Journal Scope:

    Quarterly published in print and online ‘Inventi Rapid/Impact: Med Chem’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under medicinal and pharmaceutical chemistry. It welcomes articles pertaining to design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or ligands employed as pharmaceutical tools; molecular modifications of reported series leading to improved understanding of SAR; structural biological studies of relevant ligands and targets; computational chemistry methods; effect of molecular structure on biopharmaceutics, etc.

  • SILDENAFIL AND ITS DERIVATIVES SYNTHESIS APPROACHES: A REVIEW
    Vikrant Verma*    Download Full Text

    Sildenafil is a selective inhibitor of phosphodiesterase 5 (PDE5) and is the first agent with this mode of action for the treatment of male erectile dysfunction. There has recently been an explosion of interest in sexual dysfunction. Erectile dysfunction (ED) is defined as the persistent inability to achieve and/or maintain an erection sufficient for satisfactory sexual activity. This article aims...

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  • A REVIEW ON DISSIMILAR METHODOLOGY FOR THE SYNTHESIS OF AZEPINES
    Vikrant Verma*    Download Full Text

    Azepines are seven-membered heterocycles with one nitrogen atom. This class of heterocyclic compounds is important because this scaffold is found in the molecular skeleton of many pharmaceuticals, such as cetiedil and mecillinam and some natural products. Azepines and their partly or fully reduced congeners are found as constituents of the wide range of natural products and pharmaceutically import...

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  • A REVIEW ON SEVERAL APPROACHES FOR THE SYNTHESIS OF HYDRAZONES
    Vikrant Verma*    Download Full Text

    We report here the synthesis of a series of different hydrazones with the help of different reaction schemes. Various reactions are discussed for the synthesis of hydrazones having various biological activities. Hydrazone moiety is comparable to be a potential modification source by different substituents to enhance the biological activity and reduce cytotoxiciy of novel derivatives. Each scheme h...

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  • A REVIEW ON BIOLOGICAL ACTIVITIES OF HYDRAZONE AND HYDRAZIDE DERIVATIVES
    Vikrant Verma*    Download Full Text

    Hydrazides and hydrazones are present in many of the bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. This created interest in researchers who have synthesized variety of hydrazide and hydrazone derivatives and screened them for their various biological activities viz. anticancer, antifungal, antimycobacterial, anti-inflammat...

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  • HONOKIOL ANALOGS AS ANTICANCER DRUGS
    Verma Vikrant *    Download Full Text

    Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical str...

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  • SYNTHESIS OF NOVEL 2,5-DISUBSTITUTED 1,3,4-THIADIAZOLE FOR THEIR POTENTIAL ANTICONVULSANT AND ANTIMICROBIAL SCREENING: PHARMACOPHORE MODEL STUDIES
    Tripti Verma*, Rajesh Kumar Yadav, Rajesh Asija    Download Full Text

    The 1,3,4,-Thiadiazole nucleus is a ubiquitous feature of many pharmacological activities, as anti-TB, anti-inflammatory,anti-bacterial, anti-oxidizing agents, anti-fungal, anti-cancer, anticonvulsant and antidepressants activity. It could be evidence from literature that substituted hydrazones derivative of 1,3,4-thiadiazole is not reported. Thus in the present study we synthesized novel 2,5-disu...

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