Inventi Rapid - Pharmacokinetics & Pharmacodynamics
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharmacokinetics & Pharmacodynamics’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on all areas of pharmacokinetics and pharmacodynamics of drug substances and products including drug absorption, distribution, metabolism and excretion, and application of pharmacokinetics principles for effective management of drugs. Articles from the areas such as drug action, clinical pharmacokinetics, drug metabolites, dosage form evaluation in animals and humans, bioavailabilty studies, scaling from animals to humans, and in vitro and in vivo correlations are also welcome.
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EFFECT OF PIPERINE ON ANTIHYPERLIPIDEMIC ACTIVITY AND PHARMACOKINETIC PROFILE OF SIMVASTATIN
Piperine is an alkaloid isolated from Piper nigrum Linn., (family-Piperaceae) a natural bioenhancer and is known to enhance the bioavailability of the drugs by inhibiting cytochrome P450. In the present study, the effect of piperine was investigated on antihyperlipidemic properties of simvastatin (SV) and the effects were supported with measurement of plasma concentrations. The results confirm tha...
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PHARMACOKINETICS STUDIES ON 5?-REDUCTASE INHIBITOR TRB-263 (17-OXIMINO-5 ANDROSTEN-3?-OL)
Steroidal esters of 17-oximino-5 androsten-3ß-ol were synthesized from dehydroandrosterone acetate. These compounds were tested for their antiproliferating activity and 5a-Reductase inhibitory activity in comparison to finasteride. Decreased androgen levels have been found in serum of animals treated with newly synthesized compounds. These compounds have shown better cytotoxicity as comparison ...
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PHARMACOSCINTIGRAPHY AND ITS APPLICATIONS: A REVIEW
One of the most quick and comprehensive way of determining the in-vivo pharmacokinetic profile is gamma scintigraphic study of labelled bio-medicals, materials and pharmaceuticals with radiation emitting isotopes. The formation of chemical bond between isotope and drug using a chelating agent gives a formulation called as radiopharmaceutical. Binding of two components is radiolabeling. The tagging...
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A SIMPLE NON-INVASIVE METHYL NICOTINATE MODEL WAS STANDARDIZED AND ITS APPLICATION TO A RANDOMIZED, COMPARATIVE CONTROLLED STUDY OF DEXIBUPROFEN TABLETS IN HEALTHY HUMAN MALE VOLUNTEERS
In the present study, a non-invasive, methyl nicotinate (MN) induced erythema model using Laser Doppler Flowmeter was standardized and successfully validated to perform the effect-time study on healthy human male volunteers after oral administration of 400 mg tablets of dexibuprofen. MN was applied on the volar region of forearm (20 µl) for 6 min to produce a visible vasodilation i.e. increase ...
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PHARMACOKINETIC AND SAFETY STUDY OF ASPIRIN SUPPOSITORIES AND ASPIRIN NANOPARTICLES LOADED SUPPOSITORIES
The main aim and objective of the present work was to study the pharmacokinetic and safety of aspirin suppositories and aspirin nanoparticle loaded suppositories. Aspirin nanoparticles were prepared based on ionicgelation method using sodium tripolyphosphate as cross linking agent. The Prepared nanoparticles were evaluated for characteristic studies and optimized Fa9 formulation was isolated. Aspi...
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FORMULATION AND RELEASES KINETIC STUDIES OF TRANSDERMAL PATCHES OF METFORMIN USED IN TYPE II DIABETES MELLITUS
A novel transdermal patch of Metformin was prepared for the sustained release of drug. The transdermal patch of metformin was prepared by solvent casting technique. Bioavailability of metformin is 50-60% and half life is 6.2 hr. HPMC-E50LV, HPMC-E100M and ethyl cellulose was used for matrixing agent and PEG-400 is used as plasticizer. DMSO (dimethyl sulphoxide) is used as penetration enhancer. Met...
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