Inventi Rapid - Pharmaceutical Process Development
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharmaceutical Process Development’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on multidimensional aspects of pharmaceutical process development, particularly – ingredients and equipment selection, scale-up and pilot plant studies, factoring environment, automaton and robotic procedures, in-process characterization, bioprocesses etc.
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SOLUBILITY ENHANCEMENT METHOD OF POORLY WATER SOLUBLE DRUG BY MICROWAVE ASSISTED AMORPHIZATION
By in-situ amorphization one can amorphize a given drug in its final dosage form. In present work the feasibility of microwave irradiation to enhance the dissolution rate and solubility of poorly water soluble BCS class II antidiabetic drug (glipizide) was investigated. GZ and PVP K90 were tableted by direct compression technology at 1:2, 1:3, 1:4, 1:5 and 1:6 ratios. To study the effect of energy...
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THE PROMISING TECHNIQUE IN TIME DEPENDENT DRUG RELEASE SYSTEM: CHRONOTHERAPEUTICS
The reason of writing this review on chronotherapeutic drug delivery systems is to emphasize the literatures with special focus on chontherapeutics and the various dosage forms, techniques that are used to intentionally focus on the circadian rhythms of various diseases. Current research in the field of drug delivery devices, by which pulsatile release is achieved, has been made stronger mark in p...
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FORMULATION, DEVELOPMENT AND EVALUATION OF GEL CONTAINING PSIDIUM GUAJAVA LEAVES EXTRACTS BY DESIGN EXPERT APPROACH
Psidium guajava Linn (Myrtaceae) has been used as traditional medicine. The aim of the present research work was to investigate the gel formulation containing hydroalcoholic and methanolic extract of Psidium guajava leaves. Quercetin was taken as marker and it shows good in-vitro drug release from the results it was concluded that psidium guajava leaves extract when formulated in gel show signific...
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DICLOFENAC SODIUM LOADED SUSTAINED RELEASE MATRIX TABLET POSSESSING HYDROPHOBIC POLYMERS: FORMULATION AND IN-VITRO CHARACTERIZATION BY USING MELT GRANULATION
Sustained release products are designed to release their medication in a controlled manner, at a predetermined rate, duration and location to achieve and maintain optimum therapeutic blood levels of drug. In case of simple matrix tablet, use of drug with high water solubility is accompanied by problems, i.e. relatively large amount of release-delaying agent is needed and the size of tablet as well...
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SOLID DISPERSIONS: SOLUBILITY ENHANCEMENT TECHNIQUE FOR CINNARIZINE POORLY WATER SOLUBLE DRUGS
Solid dispersions have been known to be one amongst the recent means of improving the dissolution rate by enhancement of solubility and hence the bioavailability of poorly water soluble drugs. Solid dispersion nothing to the “The dispersion of one or more active ingredients in an inert carrier or matrix, where the active ingredients could exist in finely crystalline, solubilized or amorphous...
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QUALITY BY DESIGN (QBD) PRINCIPLES AND APPLICATIONS IN PRODUCT DEVELOPMENT: AN OVERVIEW
The purpose of present article is to discuss the concept of pharmaceutical Quality by Design (QbD) and describe how it can be help to ensure pharmaceutical quality. Quality by Design is the modern approach for quality of pharmaceuticals. There is much confusion among pharmaceutical scientists in generic drug industry about the appropriate element and terminology of quality by design. Implementatio...
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