Inventi Rapid - Pharmaceutical Process Development
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Journal Scope:
Quarterly published in print and online ‘Inventi Rapid/Impact: Pharmaceutical Process Development’ publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on multidimensional aspects of pharmaceutical process development, particularly – ingredients and equipment selection, scale-up and pilot plant studies, factoring environment, automaton and robotic procedures, in-process characterization, bioprocesses etc.
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OPTIMIZATION AND DEVELOPMENT OF FAST DISINTEGRATING LIQUISOLID COMPACT OF SERTRALINE HYDROCHLORIDE FOR DISSOLUTION ENHANCEMENT USING FACTORIAL DESIGN
The objective of this study was to optimize and develop fast disintegrating liquisolid compact of sertraline hydrochloride to enhance the dissolution and study the dissolution in different pH conditions. Fast disintegrating liquisolid compacts were prepared from Neusilin US2 as a carrier material, Aeroperl 300 as a coating material, crospovidone as a superdisintegrants and Tween80 as a non-volatil...
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SOLUBILITY ENHANCEMENT OF TINIDAZOLE BY POLOXAMER AND GELUCIRE SOLID DISPERSION
Low solubility is the major problem reported with various active pharmaceutical ingredients which ultimately affects onset of action and therapeutic profile of that drug. Hence present study focused on solubility enhancement of tinidazole; a widely used antiprotozoal, antiamoebic, antibacterial agent belonging to BCS-II with low solubility and high permeability. Tinidazole solid dispersion prepare...
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SOLUBILITY ENHANCEMENT METHOD OF POORLY WATER SOLUBLE DRUG BY MICROWAVE ASSISTED AMORPHIZATION
By in-situ amorphization one can amorphize a given drug in its final dosage form. In present work the feasibility of microwave irradiation to enhance the dissolution rate and solubility of poorly water soluble BCS class II antidiabetic drug (glipizide) was investigated. GZ and PVP K90 were tableted by direct compression technology at 1:2, 1:3, 1:4, 1:5 and 1:6 ratios. To study the effect of energy...
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THE PROMISING TECHNIQUE IN TIME DEPENDENT DRUG RELEASE SYSTEM: CHRONOTHERAPEUTICS
The reason of writing this review on chronotherapeutic drug delivery systems is to emphasize the literatures with special focus on chontherapeutics and the various dosage forms, techniques that are used to intentionally focus on the circadian rhythms of various diseases. Current research in the field of drug delivery devices, by which pulsatile release is achieved, has been made stronger mark in p...
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FORMULATION, DEVELOPMENT AND EVALUATION OF GEL CONTAINING PSIDIUM GUAJAVA LEAVES EXTRACTS BY DESIGN EXPERT APPROACH
Psidium guajava Linn (Myrtaceae) has been used as traditional medicine. The aim of the present research work was to investigate the gel formulation containing hydroalcoholic and methanolic extract of Psidium guajava leaves. Quercetin was taken as marker and it shows good in-vitro drug release from the results it was concluded that psidium guajava leaves extract when formulated in gel show signific...
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DICLOFENAC SODIUM LOADED SUSTAINED RELEASE MATRIX TABLET POSSESSING HYDROPHOBIC POLYMERS: FORMULATION AND IN-VITRO CHARACTERIZATION BY USING MELT GRANULATION
Sustained release products are designed to release their medication in a controlled manner, at a predetermined rate, duration and location to achieve and maintain optimum therapeutic blood levels of drug. In case of simple matrix tablet, use of drug with high water solubility is accompanied by problems, i.e. relatively large amount of release-delaying agent is needed and the size of tablet as well...
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